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Dev Cell. 2011 May 17;20(5):578-80. doi: 10.1016/j.devcel.2011.05.002.

Coordinating migratory neuron polarization by numb-ing communication.

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1
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Abstract

An interplay between intrinsic polarity and extracellular cues guides neuronal migration during cerebellar development. In this issue of Developmental Cell, Zhou et al. (2011) demonstrate that Numb is the focal point in mediating the chemotactic response of migrating cerebellar granule cells to BDNF through its regulation of cell polarity.

PMID:
21571215
DOI:
10.1016/j.devcel.2011.05.002
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