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Curr Biol. 2011 Apr 26;21(8):R280-2. doi: 10.1016/j.cub.2011.03.035.

Invadopodia: RhoC runs rings around cofilin.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. stacey.macgrath@yale.edu

Abstract

Tumor cell invadopodia mediate degradation of matrix barriers. A new study now demonstrates that a ring of active RhoC focuses invadopodial protrusion and degradation by regulating cofilin activity.

PMID:
21514509
PMCID:
PMC3376399
DOI:
10.1016/j.cub.2011.03.035
[Indexed for MEDLINE]
Free PMC Article

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