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Items: 7

1.

Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.

McDonald CB, Bhat V, Kurouski D, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK, Farooq A.

Biophys Chem. 2013 May-Jun;175-176:54-62. doi: 10.1016/j.bpc.2013.02.008. Epub 2013 Mar 5.

2.

Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.

McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

J Mol Recognit. 2013 Feb;26(2):92-103. doi: 10.1002/jmr.2256.

3.

Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.

McDonald CB, Buffa L, Bar-Mag T, Salah Z, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Malhotra A, Sudol M, Aqeilan RI, Nawaz Z, Farooq A.

J Mol Biol. 2012 Sep 7;422(1):58-74. doi: 10.1016/j.jmb.2012.05.015. Epub 2012 May 23.

4.

Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.

McDonald CB, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

FEBS J. 2012 Jun;279(12):2156-73. doi: 10.1111/j.1742-4658.2012.08600.x. Epub 2012 May 9.

5.

Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

Biochemistry. 2012 Mar 13;51(10):2122-35. doi: 10.1021/bi3000534. Epub 2012 Mar 2.

6.

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

McDonald CB, McIntosh SK, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z, Farooq A.

Biochemistry. 2011 Nov 8;50(44):9616-27. doi: 10.1021/bi201286p. Epub 2011 Oct 14.

7.

Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

J Mol Recognit. 2011 Jul-Aug;24(4):585-96. doi: 10.1002/jmr.1080. Epub 2010 Dec 13.

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