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Chem Biol. 2011 Mar 25;18(3):293-8. doi: 10.1016/j.chembiol.2011.01.013.

Structural basis of cooperative ligand binding by the glycine riboswitch.

Author information

1
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA.

Abstract

The glycine riboswitch regulates gene expression through the cooperative recognition of its amino acid ligand by a tandem pair of aptamers. A 3.6 Å crystal structure of the tandem riboswitch from the glycine permease operon of Fusobacterium nucleatum reveals the glycine binding sites and an extensive network of interactions, largely mediated by asymmetric A-minor contacts, that serve to communicate ligand binding status between the aptamers. These interactions provide a structural basis for how the glycine riboswitch cooperatively regulates gene expression.

PMID:
21439473
PMCID:
PMC3076126
DOI:
10.1016/j.chembiol.2011.01.013
[Indexed for MEDLINE]
Free PMC Article

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