Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2010 Dec;1214:E1-E17. doi: 10.1111/j.1749-6632.2010.05917.x.

Mendelian genetics of male infertility.

Author information

  • 1Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.

Abstract

Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive techniques (ART), we are now able to overcome sterility and bypass nature's protective mechanisms that developed through evolution to prevent fertilization by defective or deficient sperm.

PMID:
21382200
PMCID:
PMC3654696
DOI:
10.1111/j.1749-6632.2010.05917.x
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center