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Cancer Epidemiol Biomarkers Prev. 2011 May;20(5):1039-42. doi: 10.1158/1055-9965.EPI-11-0135. Epub 2011 Feb 25.

No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies.

Author information

1
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. fangchen@usc.edu

Abstract

BACKGROUND:

Body mass index is an established risk factor for postmenopausal breast cancer. Epidemiologic studies have also reported a positive association between type 2 diabetes (T2D) and breast cancer risk.

METHODS:

To investigate a genetic basis linking these common phenotypes with breast cancer, we tested 31 common variants for T2D and obesity in a case-control study of 1,915 breast cancer cases and 2,884 controls nested within the Multiethnic Cohort (MEC) study.

RESULTS:

Following adjustment for multiple tests, we found no significant association between any variant and breast cancer risk. Summary scores comprising the numbers of risk alleles for T2D and/or obesity were also not found to be significantly associated with breast cancer risk.

CONCLUSIONS:

Our findings provide no evidence for association between established T2D and/or obesity risk variants and breast cancer risk among women of various ethnicities.

IMPACT:

These results suggest that the potential for a shared biology between T2D/obesity and breast cancer is not due to pleiotropic effects of these risk variants.

PMID:
21357383
PMCID:
PMC4201112
DOI:
10.1158/1055-9965.EPI-11-0135
[Indexed for MEDLINE]
Free PMC Article

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