Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Reprod Dev. 2011 Mar;78(3):151-60. doi: 10.1002/mrd.21289. Epub 2011 Feb 17.

Extrinsic and intrinsic control of germ cell proliferation in Caenorhabditis elegans.

Author information

1
Department of Genetics, Yale University, New Haven, CT 06520, USA.

Abstract

The germ cells of Caenorhabditis elegans serve as a useful model to study the balance between proliferation and differentiation within the context of development and changing environmental signals experienced by the animal. Germ cells adjacent to a stem cell niche in the distal region of the gonad retain the capacity to divide during adulthood, making them unique from other cells in the organism. We will highlight recent advances in our understanding of mechanisms that control proliferation, as well as the signaling pathways involved in promoting mitosis at the expense of differentiation.

PMID:
21337453
PMCID:
PMC3375679
DOI:
10.1002/mrd.21289
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center