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J Virol. 2011 May;85(9):4602-5. doi: 10.1128/JVI.02491-10. Epub 2011 Feb 16.

Vesicular stomatitis virus-based H5N1 avian influenza vaccines induce potent cross-clade neutralizing antibodies in rhesus macaques.

Author information

1
Department of Pathology, Yale University School of Medicine, 310 Cedar St. LH 315, New Haven, CT 06520, USA.

Abstract

We analyzed the ability of a vaccine vector based on vesicular stomatitis virus (VSV) to induce a neutralizing antibody (NAb) response to avian influenza viruses (AIVs) in rhesus macaques. Animals vaccinated with vectors expressing either strain A/Hong Kong/156/1997 or strain A/Vietnam/1203/2004 H5 hemagglutinin (HA) were able to generate robust NAb responses. The ability of the vectors to induce NAbs against homologous and heterologous AIVs after a single dose was dependent upon the HA antigen incorporated into the VSV vaccine. The vectors expressing strain A/Vietnam/1203/2004 H5 HA were superior to those expressing strain A/Hong Kong/156/1997 HA at inducing cross-clade NAbs.

PMID:
21325423
PMCID:
PMC3126271
DOI:
10.1128/JVI.02491-10
[Indexed for MEDLINE]
Free PMC Article

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