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J Clin Lipidol. 2009 Apr;3(2):78-84. doi: 10.1016/j.jacl.2009.02.006. Epub 2009 Feb 11.

Postprandial lipemia as an early predictor of cardiovascular complications in childhood obesity.

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Alberta Institute for Human Nutrition, 4-10 Agriculture Forestry Centre, Edmonton, Alberta, T6G 2P5, Canada (Ms. Su, Ms. Nzekwu, and Dr. Proctor); and Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada (Drs. Ball and Jetha).


The growing trend of childhood overweight and obesity is a major health concern worldwide. Although obesity is a key risk factor for cardiovascular disease, the etiologic link between obesity and the progression of vascular disease remains unknown. Traditionally, lowering fasting blood cholesterol concentration has been the main interventional target for decreasing the risk of heart disease. However, there is increasing evidence that elevated concentrations of intestinally-derived chylomicron particles are associated with cardiovascular disease risk and that this is particularly evident in insulin-resistance and obesity in adulthood. In this review we comment on recent evidence suggesting that overweight children have fasting chylomicron concentrations equivalent to that found in adults diagnosed with cardiovascular disease. Further, we consider the hypothesis that fasting and postprandial chylomicron metabolism has a central role in the genesis of cardiovascular disease during childhood obesity.


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