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Adv Exp Med Biol. 2011;704:287-313. doi: 10.1007/978-94-007-0265-3_16.

TRPP channels and polycystins.

Author information

1
Renal Division, Department of Medicine, University Medical Centre Freiburg, 79106 Freiburg, Germany. alexis.hofherr@uniklinik-freiburg.de

Abstract

The founding member of the TRPP family, TRPP2, was identified as one of the disease genes causing autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most prevalent, potentially lethal, monogenic disorder in humans, with an average incidence of one in 400 to one in 1,000 individuals worldwide. Here we give an overview of TRPP ion channels and Polycystin-1 receptor proteins focusing on more recent studies. We include the Polycystin-1 family since these proteins are functionally linked to TRPP channels.

PMID:
21290302
DOI:
10.1007/978-94-007-0265-3_16
[Indexed for MEDLINE]

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