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Am J Physiol Renal Physiol. 2011 Apr;300(4):F821-7. doi: 10.1152/ajprenal.00742.2010. Epub 2011 Jan 26.

Recent advances in distal tubular potassium handling.

Author information

1
Division of Nephrology, Department of Medicine, UT, USA.

Abstract

It is well known that sodium reabsorption and aldosterone play important roles in potassium secretion by the aldosterone-sensitive distal nephron. Sodium- and aldosterone-independent mechanisms also exist. This review focuses on some recent studies that provide novel insights into the sodium- and aldosterone-independent potassium secretion by the aldosterone-sensitive distal nephron. In addition, we discuss a study reporting on the regulation of the mammalian potassium kidney channel ROMK by intracellular and extracellular magnesium, which may be important in the pathogenesis of persistent hypokalemia in patients with concomitant potassium and magnesium deficiency. We also discuss outstanding questions and propose working models for future investigation.

PMID:
21270092
PMCID:
PMC3074996
DOI:
10.1152/ajprenal.00742.2010
[Indexed for MEDLINE]
Free PMC Article

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