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Cell Host Microbe. 2011 Jan 20;9(1):1-2. doi: 10.1016/j.chom.2011.01.002.

Understanding how hepatitis C virus builds its unctuous home.

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Section of Microbial Pathogenesis, Yale School of Medicine, 295 Congress Avenue, BCMM 354C, New Haven, CT 06536, USA.


Hepatitis C virus genome replication occurs in endoplasmic reticulum-derived membrane compartments, but it is unknown how these structures arise. In this issue of Cell Host & Microbe, Reiss and colleagues (2011) show that the virus recruits a specific lipid kinase to replication sites, stimulates its kinase activity, and alters the phospholipid profile of replication compartments.

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