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J Comput Assist Tomogr. 2011 Jan-Feb;35(1):39-42. doi: 10.1097/RCT.0b013e3181f31917.

Posterior reversible encephalopathy syndrome (PRES) with immune system activation, VEGF up-regulation, and cerebral amyloid angiopathy.

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1
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

The case of a 75-year-old man with a history of lymphoma, recent upper respiratory tract infection, and a protracted course of encephalopathy is presented. Radiologically, findings were consistent with posterior reversible encephalopathy syndrome. A brain biopsy revealed evidence of endothelial activation, T-cell trafficking, and vascular endothelial growth factor expression, suggesting that systemic immune system activation may be involved with triggering posterior reversible encephalopathy syndrome. In addition, underlying cerebral amyloid angiopathy may have contributed to the initial nonclassical edema distribution by compromising autoregulatory blood flow mechanisms.

PMID:
21150450
DOI:
10.1097/RCT.0b013e3181f31917
[Indexed for MEDLINE]
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