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Curr Opin Immunol. 2011 Feb;23(1):21-8. doi: 10.1016/j.coi.2010.11.004. Epub 2010 Nov 29.

Gaining a foothold: how HIV avoids innate immune recognition.

Author information

1
Immune Disease Institute and Program in Cellular and Molecular Medicine, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States.

Abstract

During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in infected CD4 T cells and macrophages by harnessing a host cytoplasmic DNase TREX1 to digest nonproductive HIV reverse transcripts.

PMID:
21123040
PMCID:
PMC3042516
DOI:
10.1016/j.coi.2010.11.004
[Indexed for MEDLINE]
Free PMC Article
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