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Immunity. 2010 Oct 29;33(4):578-80. doi: 10.1016/j.immuni.2010.10.003.

Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way.

Author information

1
Department of Pediatrics, Division of Gastroenterology and Harvard Medical School, Children's Hospital Boston, 300 Longwood Ave, Enders 730.2, Boston, MA 02115, USA. jonathan.kagan@childrens.harvard.edu

Abstract

The ability of Toll-like receptors (TLRs) to activate innate immunity depends on their transport to pathogen-containing organelles. In this issue of Immunity, Husebye et al. (2010) report that delivery of TLR4 to phagosomes occurs via a recycling endosome intermediate, which is controlled by the GTPase Rab11a.

PMID:
21029967
DOI:
10.1016/j.immuni.2010.10.003
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