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Science. 2010 Nov 12;330(6006):980-2. doi: 10.1126/science.1194516. Epub 2010 Oct 21.

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

Author information

1
Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.

Abstract

The intracerebral injection of β-amyloid-containing brain extracts can induce cerebral β-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with β-amyloid-rich extracts induced β-amyloidosis in the brains of β-amyloid precursor protein transgenic mice after prolonged incubation times.

PMID:
20966215
PMCID:
PMC3233904
DOI:
10.1126/science.1194516
[Indexed for MEDLINE]
Free PMC Article

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