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Neurosci Lett. 2011 Jan 3;487(1):107-9. doi: 10.1016/j.neulet.2010.10.005. Epub 2010 Oct 16.

Purinergic activation of dorsal root ganglion neurones in vivo.

Author information

1
Department of Neurogenetics, Max-Planck-Institute for Experimental Medicine, Göttingen, Germany.

Abstract

Functional relevance of non-synaptic purinergic receptors on dorsal root ganglion cells was tested in vivo by the influence of ATP using 2P-LSM and Ca imaging. Within a few seconds after local application of ATP, neurones in dorsal root ganglion were activated indicated by an increase of their calcium signal. The signal reached its maximum within a few seconds and declined to control values after about 30 s. Purinergic action seems to include non-synaptic cell-to-cell communication within dorsal root ganglia.

PMID:
20937358
DOI:
10.1016/j.neulet.2010.10.005
[Indexed for MEDLINE]

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