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Aging (Albany NY). 2010 Jun;2(6):369-74.

Sestrins at the crossroad between stress and aging.

Author information

1
Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA.

Abstract

Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.

PMID:
20606249
PMCID:
PMC2919257
DOI:
10.18632/aging.100157
[Indexed for MEDLINE]
Free PMC Article

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