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Med Image Comput Comput Assist Interv. 2001 Sep 2;3216(2004):763-770.

Integrated Intensity and Point-Feature Nonrigid Registration.

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Department of Biomedical Engineering, Yale University New Haven, CT 06520-8042.


In this work, we present a method for the integration of feature and intensity information for non rigid registration. Our method is based on a free-form deformation model, and uses a normalized mutual information intensity similarity metric to match intensities and the robust point matching framework to estimate feature (point) correspondences. The intensity and feature components of the registration are posed in a single energy functional with associated weights. We compare our method to both point-based and intensity-based registrations. In particular, we evaluate registration accuracy as measured by point landmark distances and image intensity similarity on a set of seventeen normal subjects. These results suggest that the integration of intensity and point-based registration is highly effective in yielding more accurate registrations.

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