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Am J Obstet Gynecol. 2010 Jun;202(6):614.e1-8. doi: 10.1016/j.ajog.2010.01.028. Epub 2010 Apr 28.

Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study.

Author information

1
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA.

Abstract

OBJECTIVE:

The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients.

STUDY DESIGN:

In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-alpha and -beta, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test.

RESULTS:

Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P < .0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression.

CONCLUSION:

Markers of inflammation differed between primary and secondary vestibulodynia and controls.

PMID:
20430353
DOI:
10.1016/j.ajog.2010.01.028
[Indexed for MEDLINE]

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