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Eur Heart J. 2011 Jan;32(1):115-23. doi: 10.1093/eurheartj/ehq108. Epub 2010 Apr 25.

Decreased serine207 phosphorylation of troponin T as a biomarker for left ventricular remodelling after myocardial infarction.

Author information

1
INSERM U744, Lille, France.

Abstract

AIMS:

Chronic heart failure following myocardial infarction (MI) is characterized by progressive left ventricular remodelling (LVR). Despite significant improvements in MI management, LVR remains a frequent complication. Although several risk factors have been identified, such as infarct size, LVR is difficult to predict in clinical practice.

METHODS AND RESULTS:

Using a rat model of MI and phosphoproteomic technology, we discovered that remodelling is associated with decreased levels of myocardial and plasma serine(208)-phosphorylated troponin T (TnT). To confirm the association in human plasma, we developed new specific polyclonal antibodies against human/rat serine(207/208)-phosphorylated TnT and tested plasma obtained in the first week after MI from patients with low, intermediate, and high remodelling a year later. We observed a significant decrease of serine(207)-phosphorylated TnT and of the serine(207)-phosphorylated TnT/total TnT ratio in those with intermediate or high LVR. These differences remained statistically significant when adjusted for other determinants of LVR. In contrast, baseline B-type natriuretic peptide levels were not associated with LVR.

CONCLUSION:

The level of circulating phosphorylated TnT could be a new biomarker of LVR.

PMID:
20418543
DOI:
10.1093/eurheartj/ehq108
[Indexed for MEDLINE]

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