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Genes Dev. 2010 Apr 15;24(8):741-7. doi: 10.1101/gad.1920710.

A wheel of time: the circadian clock, nuclear receptors, and physiology.

Author information

1
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA. xiaoyong.yang@yale.edu <xiaoyong.yang@yale.edu>

Abstract

It is a long-standing view that the circadian clock functions to proactively align internal physiology with the 24-h rotation of the earth. Recent studies, including one by Schmutz and colleagues (pp. 345-357) in the February 15, 2010, issue of Genes & Development, delineate strikingly complex connections between molecular clocks and nuclear receptor signaling pathways, implying the existence of a large-scale circadian regulatory network coordinating a diverse array of physiological processes to maintain dynamic homeostasis.

PMID:
20395363
PMCID:
PMC2854389
DOI:
10.1101/gad.1920710
[Indexed for MEDLINE]
Free PMC Article

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