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Ann N Y Acad Sci. 2010 Mar;1192:161-9. doi: 10.1111/j.1749-6632.2009.05249.x.

Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation.

Author information

1
Yale University School of Medicine, New Haven, Connecticut, USA. john.wysolmerski@yale.edu

Abstract

Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. As a result, lactation is associated with dramatic alterations in bone and mineral metabolism, including reversible bone loss. One theme that has emerged from recent studies examining these adaptations is that the lactating breast actively participates in regulating bone and mineral metabolism. This review will detail our current knowledge of interactions between the breast, skeleton, and hypothalamus during lactation and will consider implications that this reproductive physiology has for the pathophysiology of osteoporosis and breast cancer.

PMID:
20392232
PMCID:
PMC3777748
DOI:
10.1111/j.1749-6632.2009.05249.x
[Indexed for MEDLINE]
Free PMC Article

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