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Arch Ophthalmol. 2010 Apr;128(4):443-7. doi: 10.1001/archophthalmol.2010.31.

Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity.

Author information

1
Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. carolyn.wu@childrens.harvard.edu

Abstract

OBJECTIVE:

To validate longitudinal postnatal weight gain as a method for predicting severe retinopathy of prematurity (ROP) in a US cohort.

METHODS:

Both ROP evaluations and weekly weight measurements from birth to postmenstrual week 36 for 318 infants were entered into a computer-based surveillance system, WINROP. This system signaled an alarm when the rate of weight gain decreased compared with control subjects. Infants were classified into 3 groups: (1) no alarm, (2) low-risk alarm, or (3) high-risk alarm. Maximum ROP for each infant was categorized as (1) no ROP (immature or mature vascularization), (2) mild ROP (stage 1 or 2 ROP in zone II or III, without plus disease), or (3) severe ROP (any prethreshold, any stage 3, or threshold ROP). A high-risk alarm identified infants at risk for developing severe ROP.

RESULTS:

A high-risk alarm occurred in 81 infants (25.5%) and detected all infants who developed severe ROP a median of 9 weeks before diagnosis. The remaining infants received no alarm or a low-risk alarm. None of these infants developed more than mild ROP.

CONCLUSIONS:

Longitudinal postnatal weight gain may help predict ROP. In a US cohort, the WINROP system had a sensitivity of 100% and identified infants early who developed severe ROP. With further validation, WINROP has the potential to safely reduce the number of ROP examinations.

PMID:
20385939
PMCID:
PMC4393744
DOI:
10.1001/archophthalmol.2010.31
[Indexed for MEDLINE]
Free PMC Article
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