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Brain. 2010 Apr;133(Pt 4):973-82. doi: 10.1093/brain/awq044.

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.

Author information

1
UMR975, Hôpital de la Salpêtrière, Université Pierre et Marie Curie, Paris, France. soufiane.elhallani@yahoo.ca

Abstract

Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a hallmark of the disease. A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown a high but transient efficacy. We analysed human glioblastoma tissues and found non-endothelial cell-lined blood vessels that were formed by tumour cells (vasculogenic mimicry of the tubular type). We hypothesized that CD133+ glioblastoma cells presenting stem-cell properties may express pro-vascular molecules allowing them to form blood vessels de novo. We demonstrated in vitro that glioblastoma stem-like cells were capable of vasculogenesis and endothelium-associated genes expression. Moreover, a fraction of these glioblastoma stem-like cells could transdifferentiate into vascular smooth muscle-like cells. We describe here a new mechanism of alternative glioblastoma vascularization and open a new perspective for the antivascular treatment strategy.

PMID:
20375132
PMCID:
PMC4861203
DOI:
10.1093/brain/awq044
[Indexed for MEDLINE]
Free PMC Article

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