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Exp Physiol. 2010 Apr;95(4):471-8. doi: 10.1113/expphysiol.2009.049445.

Evidence for intestinal chloride secretion.

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1
Department of Surgery, Yale School of Medicine, New Haven, CT 06511, USA.

Abstract

Intestinal fluid secretion is pivotal in the creation of an ideal environment for effective enzymatic digestion, nutrient absorption and stool movement. Since fluid cannot be actively secreted into the gut, this process is dependent on an osmotic gradient, which is mainly created by chloride transport by the enterocyte. A pathological dysbalance between fluid secretion and absorption leads to obstruction or potentially fatal diarrhoea. This article reviews the widely accepted model of intestinal chloride secretion with an emphasis on the molecular players involved in this tightly regulated process.

PMID:
20233891
DOI:
10.1113/expphysiol.2009.049445
[Indexed for MEDLINE]
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