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Front Immunol. 2018 Aug 10;9:1803. doi: 10.3389/fimmu.2018.01803. eCollection 2018.

Advances in Designing and Developing Vaccines, Drugs, and Therapies to Counter Ebola Virus.

Author information

1
Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.
2
Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, India.
3
Department of Biochemistry and Genetics, Barkatullah University, Bhopal, India.
4
Department of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, Agartala, India.
5
Immunology Section, ICAR-Indian Veterinary Research Institute, Bareilly, India.
6
Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Bareilly, India.
7
Division of Virology, ICAR-Indian Veterinary Research Institute, Nainital, Uttarakhand, India.
8
Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, India.
9
Division of Veterinary Public Health, ICAR-Indian Veterinary Research Institute, Bareilly, India.
10
ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
11
Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine SIriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola virus disease (EVD) (formerly named Ebola hemorrhagic fever). This is a severe, often fatal illness with mortality rates varying from 50 to 90% in humans. Although the virus and associated disease has been recognized since 1976, it was only when the recent outbreak of EBOV in 2014-2016 highlighted the danger and global impact of this virus, necessitating the need for coming up with the effective vaccines and drugs to counter its pandemic threat. Albeit no commercial vaccine is available so far against EBOV, a few vaccine candidates are under evaluation and clinical trials to assess their prophylactic efficacy. These include recombinant viral vector (recombinant vesicular stomatitis virus vector, chimpanzee adenovirus type 3-vector, and modified vaccinia Ankara virus), Ebola virus-like particles, virus-like replicon particles, DNA, and plant-based vaccines. Due to improvement in the field of genomics and proteomics, epitope-targeted vaccines have gained top priority. Correspondingly, several therapies have also been developed, including immunoglobulins against specific viral structures small cell-penetrating antibody fragments that target intracellular EBOV proteins. Small interfering RNAs and oligomer-mediated inhibition have also been verified for EVD treatment. Other treatment options include viral entry inhibitors, transfusion of convalescent blood/serum, neutralizing antibodies, and gene expression inhibitors. Repurposed drugs, which have proven safety profiles, can be adapted after high-throughput screening for efficacy and potency for EVD treatment. Herbal and other natural products are also being explored for EVD treatment. Further studies to better understand the pathogenesis and antigenic structures of the virus can help in developing an effective vaccine and identifying appropriate antiviral targets. This review presents the recent advances in designing and developing vaccines, drugs, and therapies to counter the EBOV threat.

KEYWORDS:

Ebola virus; Ebola virus disease; drugs; prophylactics; therapeutics; treatment; vaccines

PMID:
30147687
PMCID:
PMC6095993
DOI:
10.3389/fimmu.2018.01803
[Indexed for MEDLINE]
Free PMC Article

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