Format

Send to

Choose Destination
Neuron. 2010 Jan 28;65(2):147-9. doi: 10.1016/j.neuron.2010.01.013.

Excitatory neuromodulator reduces dopamine release, enhancing prolactin secretion.

Author information

1
Department of Neurosurgery, Yale University, New Haven, CT 06520, USA. anthony.vandenpol@yale.edu

Abstract

Hypothalamic dopamine neurons inhibit pituitary prolactin secretion. In this issue of Neuron, Lyons et al. provide evidence for a novel model, whereby the excitatory neuropeptide TRH depolarizes gap-junction-coupled dopamine neurons, leading to a shift in the population pattern of action potentials from phasic burst firing to regular tonic firing, hypothetically reducing dopamine release while increasing total spike number.

PMID:
20152122
PMCID:
PMC2839927
DOI:
10.1016/j.neuron.2010.01.013
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center