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Skin Pharmacol Physiol. 2010;23(2):113-6. doi: 10.1159/000265682. Epub 2009 Dec 14.

Pre-treatment with Aloe vera juice does not enhance the in vitro permeation of ketoprofen across skin.

Author information

1
Welsh School of Pharmacy, Cardiff University, Cardiff, UK.

Abstract

BACKGROUND/AIMS:

The potential of pre-treating skin with Aloe vera juice as a penetration enhancer was evaluated in vitro using ketoprofen as model permeant.

METHODS:

To excised porcine skin mounted in Franz diffusion cells was applied either: (1) commercial Aloe vera; (2) commercial Aloe vera followed by massaging; (3) previously boiled commercial Aloe vera; (4) water (negative control); (5) tea tree oil (positive control). After 1 h, the pre-treatment was removed and the skin dosed with a saturated solution of ketoprofen in polyethylene glycol 400; the appearance of drug in the receptor phase was then monitored by HPLC.

RESULTS:

No statistically significant differences in the transdermal delivery of ketoprofen were observed between water and all the Aloe vera pre-treatments (p > 0.05). The tea tree oil pre-treatment was significantly different to all others (p < 0.05).

CONCLUSION:

Aloe vera appears to have no value as a penetration enhancer when used as a pre-treatment, although the data indirectly support the mechanism of action proposed previously, work when used 'within-vehicle'. Handling household products containing Aloe vera appears not to leave the user at elevated risk of subsequent absorption of exogenous chemicals.

PMID:
20016253
DOI:
10.1159/000265682
[Indexed for MEDLINE]

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