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J Nat Prod. 2010 Feb 26;73(2):255-7. doi: 10.1021/np9005426.

A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Author information

1
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.

Abstract

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

PMID:
20000782
PMCID:
PMC2829331
DOI:
10.1021/np9005426
[Indexed for MEDLINE]
Free PMC Article

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