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Transplantation. 2009 Oct 15;88(7):874-8. doi: 10.1097/TP.0b013e3181b6eca2.

B cells are dispensable for neonatal transplant tolerance induction.

Author information

1
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Abstract

BACKGROUND:

Prior studies have demonstrated that neonatal B cells possess unique immunoregulatory properties. Specifically, neonatal B-1 cells produce interleukin (IL)-10 in response to toll-like receptor stimulation; this modulates innate and adaptive alloimmune responses. Here, we examine whether this process plays a critical role in neonatal transplant tolerance induction.

METHODS:

We used a murine model of neonatal transplant tolerance induction, whereby female C57BL/6 mice injected with male spleen cells 3 days after birth acquire the ability to accept a male skin transplant in adulthood.

RESULTS:

We investigated the role of B cells in this model by using mice with targeted genetic B-cell deficiencies (including muMT, JH-/-, and XID mice). In addition, we examined the role of IL-10 in this model using IL-10-/- mice. Transplant tolerance induction was neither dependent on B cells nor on IL-10.

CONCLUSIONS:

Despite the role of neonatal B cells in suppressing innate and adaptive alloimmune responses, B cells are dispensable for neonatal transplant tolerance induction in this experimental model.

PMID:
19935457
PMCID:
PMC2784663
DOI:
10.1097/TP.0b013e3181b6eca2
[Indexed for MEDLINE]
Free PMC Article
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