Format

Send to

Choose Destination
See comment in PubMed Commons below
Learn Mem. 2009 Nov 19;16(12):756-60. doi: 10.1101/lm.1547909. Print 2009 Dec.

Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction.

Author information

1
Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA;

Abstract

Anatomically selective medial prefrontal cortical projections regulate the extinction of stimulus-reinforcement associations, but the mechanisms underlying extinction of an instrumental response for reward are less well-defined and may involve structures that regulate goal-directed action. We show brain-derived neurotrophic factor (bdnf) knock-down in the prelimbic, but not orbitofrontal, cortex accelerates the initial extinction of instrumental responding for food and reduces striatal BDNF protein. When knock-down mice were provided with alternative response options to readily obtain reinforcement, extinction of the previously reinforced response was unaffected, consistent with the hypothesis that the prelimbic cortex promotes instrumental action, particularly when reinforcement is uncertain or unavailable.

PMID:
19926781
PMCID:
PMC2788209
DOI:
10.1101/lm.1547909
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center