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Nat Rev Mol Cell Biol. 2009 Nov;10(11):804-10. doi: 10.1038/nrm2784.

Biased segregation of DNA and centrosomes: moving together or drifting apart?

Author information

1
Stem Cells and Development Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, Paris Cedex 15, France. shaht@pasteur.fr

Abstract

Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the biased segregation of DNA strands to daughter cells during cell division. We propose that this asymmetric localization is linked to biased chromatid segregation, which might also be related to the acquisition of distinct cell fates after mitosis.

PMID:
19851338
DOI:
10.1038/nrm2784
[Indexed for MEDLINE]
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