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Bioorg Med Chem Lett. 2009 Dec 1;19(23):6682-5. doi: 10.1016/j.bmcl.2009.10.005. Epub 2009 Oct 6.

Histamine H3 and H4 receptor affinity of branched 3-(1H-imidazol-4-yl)propyl N-alkylcarbamates.

Author information

1
Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 30-688 Kraków, Poland.

Abstract

A series of imidazole-containing (non-)chiral carbamates were tested at human histamine H(3) receptor (H(3)R). All compounds displayed K(i) values below 100 nM. A trend for a stereoselectivity at human H(3)R was observed for the chiral alpha-branched ligands. Selected compounds were also tested at human histamine H(4) receptor and showed moderate to weak affinities (118-1460 nM).

PMID:
19846299
DOI:
10.1016/j.bmcl.2009.10.005
[Indexed for MEDLINE]

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