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Int J Dent Hyg. 2009 Nov;7(4):294-8. doi: 10.1111/j.1601-5037.2009.00367.x.

The influence of a hydrogen peroxide and glycerol containing mouthrinse on plaque accumulation: a 3-day non-brushing model.

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Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.



To evaluate the inhibition of plaque growth by an experimental mouthrinse (BioXyl) based on hydrogen peroxide/glycerol.


It was a double-blind, randomized study involving 40 volunteers in good general health. At the start of the trial, all participants received a dental prophylaxis to remove all plaque deposits. During the next 3 days subjects refrained from any mechanical oral hygiene procedure, except for the allocated mouthrinse being either the hydrogen peroxide (H(2)O(2); 0.013% H(2)O(2)/0.004% glycerol) or the placebo without H(2)O(2). At the third day of appointment, plaque levels were assessed at six sites per tooth.


The test group had a mean overall plaque score of 2.66 and the placebo group of 2.70. The difference in plaque scores between the two groups was not statistically significant.


The results of this pilot study showed that there was no statistically significant difference between the H(2)O(2)/glycerol group and the placebo group with respect to plaque inhibition within this study design.

[Indexed for MEDLINE]

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