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J Bacteriol. 2009 Dec;191(23):7367-71. doi: 10.1128/JB.01081-09. Epub 2009 Oct 2.

ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.

Author information

1
National Food Research Institute, Tsukuba, Ibaraki, Japan. tina2672@affrc.go.jp

Abstract

Bacillus subtilis mutants with high expression of the bacilysin operon ywfBCDEFG were isolated. Comparative genome sequencing analysis revealed that all of these mutants have a mutation in the scoC gene. The disruption of scoC by genetic engineering also resulted in increased expression of ywfBCDEFG. Primer extension and gel mobility shift analyses showed that the ScoC protein binds directly to the promoter region of ywfBCDEFG. Our results indicate that the transition state regulator ScoC, together with CodY and AbrB, negatively regulates bacilysin production in B. subtilis.

PMID:
19801406
PMCID:
PMC2786573
DOI:
10.1128/JB.01081-09
[Indexed for MEDLINE]
Free PMC Article

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