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J Palliat Med. 2009 Nov;12(11):989-91. doi: 10.1089/jpm.2009.0198.

Ketamine mouthwash for mucositis pain.

Author information

1
Department of Pharmacy, University of California San Diego, La Jolla, California 92037-1300, USA. anryan@ucsd.edu

Abstract

PURPOSE:

Our objective was to determine if an oral ketamine swish and expectorate was a safe and effective method to alleviate mucositis pain.

METHODS:

A retrospective chart audit was preformed on eight patients who received ketamine mouthwash (20 mg/5 mL) for refractory mucositis pain.

RESULTS:

All eight patients had mucositis pain refractory to a mucositis mixture (lidocaine, magnesium/aluminum hydroxide, and diphenhydramine) and opioids. An improvement in mucositis pain was seen in over half (5/8) of the patients. Four of eight patients had adverse effects that could have been associated with the ketamine mouthwash; all side effects were transient and subsided when the ketamine mouthwash was stopped.

CONCLUSION:

Ketamine swish and expectorate may be a viable treatment option in refractory mucositis pain.

PMID:
19708855
DOI:
10.1089/jpm.2009.0198
[Indexed for MEDLINE]

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