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J Med Primatol. 2009 Dec;38(6):418-24. doi: 10.1111/j.1600-0684.2009.00379.x. Epub 2009 Aug 21.

Association of monocyte chemoattractant protein-1 with adipocyte number, insulin resistance and liver function markers.

Author information

1
Division of Nutritional Sciences, Department of Human Ecology, The University of Texas at Austin, Austin, TX, USA. tbose@calpoly.edu

Abstract

BACKGROUND:

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine known to induce adipocyte dedifferentiation and insulin resistance. Inflammation, insulin resistance, and obesity have been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD).

METHODS:

Fasting plasma from 43 baboons were assayed for MCP-1, insulin, glucose, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). Adipocyte number and volume were measured via biopsies of omental adipose tissue. The homeostatic model assessment method (HOMA) was used to estimate systemic insulin resistance.

RESULTS:

Sex and age adjusted correlations were significant for MCP-1 with adipocyte number (r = -0.42; P = 0.01), adipocyte volume (r = 0.38; P = 0.02), HOMA (r = 0.45; P = 0.004), ALT (r = 0.46; P = 0.03) and AST (r = 0.45; P = 0.03).

CONCLUSIONS:

These results suggest that MCP-1 is related with adipocyte dedifferentiation and systemic insulin resistance, thereby potentially contributing to the development of NAFLD.

PMID:
19702660
PMCID:
PMC2783443
DOI:
10.1111/j.1600-0684.2009.00379.x
[Indexed for MEDLINE]
Free PMC Article

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