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Am J Clin Oncol. 2010 Apr;33(2):125-7. doi: 10.1097/COC.0b013e31819791eb.

Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin.

Author information

1
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

BACKGROUND:

Microcystic adnexal carcinoma (MAC) is a very rare cancer of the skin. It has only been described previously in case reports and small retrospective series.

OBJECTIVE:

To analyze and summarize data from the National Cancer Institute, Surveillance, Epidemiology, and End Results (SEER) database regarding MAC.

METHODS:

The SEER 1973 to 2004 database was investigated, and patients with MAC were identified. A statistical analysis was performed.

RESULTS:

Two hundred twenty-three patients were identified. Predominant site of disease was the head and neck skin (74%). There was only 1 case of recorded metastatic disease. Lymph nodes were pathologically involved in 1%. The 10-year overall survival was 86.4% (Standard Error [SE]: 3.3%). US census population-matched relative survival was 97.7% at 10 years (SE: 5.2%).

LIMITATIONS:

This study is limited by the retrospective nature of the SEER database.

CONCLUSIONS:

MAC is locally invasive, and rarely metastasizes to lymph nodes. Overall and population-matched relative survival is excellent.

PMID:
19675445
DOI:
10.1097/COC.0b013e31819791eb
[Indexed for MEDLINE]

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