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FEBS Lett. 2009 Aug 20;583(16):2654-62. doi: 10.1016/j.febslet.2009.06.049. Epub 2009 Jul 3.

The GroEL/GroES cis cavity as a passive anti-aggregation device.

Author information

1
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA. arthur.horwich@yale.edu

Abstract

The GroEL/GroES chaperonin folding chamber is an encapsulated space of approximately 65 A diameter with a hydrophilic wall, inside of which many cellular proteins reach the native state. The question of whether the cavity wall actively directs folding reactions or is playing a passive role has been open. We review past and recent observations and conclude that the chamber functions as a passive "Anfinsen cage" that prevents folding monomers from multimolecular aggregation.

PMID:
19577567
PMCID:
PMC2759771
DOI:
10.1016/j.febslet.2009.06.049
[Indexed for MEDLINE]
Free PMC Article

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