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Int J Dev Neurosci. 2009 Dec;27(8):863-71. doi: 10.1016/j.ijdevneu.2009.05.009. Epub 2009 May 29.

Modeling premature brain injury and recovery.

Author information

1
Center for Neuroscience Research, Children's National Medical Center, Washington, DC 20010, USA.

Abstract

Premature birth is a growing and significant public health problem because of the large number of infants that survive with neurodevelopmental sequelae from brain injury. Recent advances in neuroimaging have shown that although some neuroanatomical structures are altered, others improve over time. This review outlines recent insights into brain structure and function in these preterm infants at school age and relevant animal models. These animal models have provided scientists with an opportunity to explore in depth the molecular and cellular mechanisms of injury as well as the potential of the brain for recovery. The endogenous potential that the brain has for neurogenesis and gliogenesis, and how environment contributes to recovery, are also outlined. These preclinical models will provide important insights into the genetic and epigenetic mechanisms responsible for variable degrees of injury and recovery, permitting the exploration of targeted therapies to facilitate recovery in the developing preterm brain.

PMID:
19482072
PMCID:
PMC2783901
DOI:
10.1016/j.ijdevneu.2009.05.009
[Indexed for MEDLINE]
Free PMC Article

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