Format

Send to

Choose Destination
See comment in PubMed Commons below
Stroke. 2009 Aug;40(8):2869-71. doi: 10.1161/STROKEAHA.109.550699. Epub 2009 May 28.

Anticoagulation in childhood-onset arterial ischemic stroke with non-moyamoya arteriopathy: findings from the Colorado and German (COAG) collaboration.

Author information

1
Pediatric Neurology, B155, The Children's Hospital, Denver, 13123 East 16th Avenue, Aurora, CO 80045, USA. timothy.bernard@uchsc.edu

Abstract

BACKGROUND AND PURPOSE:

Childhood arterial ischemic stroke treatment guidelines recommend extended anticoagulation in cardioembolism and dissection. We sought to investigate the safety of extended anticoagulation in childhood arterial ischemic stroke with nonmoyamoya arteriopathy, for which the risk of recurrent stroke is high.

METHODS:

Thirty-seven patients with childhood-onset arterial ischemic stroke with acute arteriopathy (excluding moyamoya) were diagnosed between 1999 and 2007 and treated with anticoagulation for at least 4 weeks. Patients were followed in hospital-based cohort studies at 2 centers and systematically assessed for bleeding episodes and recurrent events.

RESULTS:

Over a cumulative anticoagulation duration of 1329 patient-months, there were no major bleeding episodes and 2 clinically relevant bleeding episodes. Cumulative probability of recurrent arterial ischemic stroke at 1 year was 14%.

CONCLUSIONS:

Anticoagulation can be used safely for secondary arterial ischemic stroke prevention in children with acute nonmoyamoya arteriopathy. Anticoagulation is worthy of evaluation in future randomized, controlled treatment trials in this disease.

PMID:
19478216
PMCID:
PMC4115644
DOI:
10.1161/STROKEAHA.109.550699
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center