Format

Send to

Choose Destination
See comment in PubMed Commons below
Vaccine. 2009 Jun 19;27(30):4025-30. doi: 10.1016/j.vaccine.2009.04.030. Epub 2009 May 3.

Impact of transmission dynamics on the cost-effectiveness of rotavirus vaccination.

Author information

1
Department of Epidemiology & Public Health, Yale University School of Medicine, New Haven, CT 06510, USA. eunha.shim@yale.edu

Abstract

The objective of this study is to estimate the cost-effectiveness of mass vaccination of US infants with the recently available rotavirus vaccine, RotaTeq. We developed a dynamic transmission model of rotavirus to incorporate herd immunity into cost-effectiveness analysis. Our study indicates that a rotavirus vaccination program would prevent about 90% of rotavirus incidence, mortality, hospitalization and emergency department visits annually. We conclude that a universal rotavirus vaccine program in the US would cost $77.30 per case averted from the health care and give a net saving of $80.75 per case averted from the societal perspectives, respectively. The cost per QALY gained was found to be $104,610 when we considered child with one caregiver, making the rotavirus vaccination program a cost-effective intervention.

PMID:
19389452
DOI:
10.1016/j.vaccine.2009.04.030
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center