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Circ Res. 2009 Feb 27;104(4):442-54. doi: 10.1161/CIRCRESAHA.108.191270.

MicroRNAs as novel regulators of angiogenesis.

Author information

1
Vascular Biology and Therapuetics Program [corrected] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.

Erratum in

  • Circ Res. 2009 Apr 10;104(7):e55.

Abstract

MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.

PMID:
19246688
PMCID:
PMC2760389
DOI:
10.1161/CIRCRESAHA.108.191270
[Indexed for MEDLINE]
Free PMC Article

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