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J Clin Psychiatry. 2009 Jan;70(1):e02.

Reviewing medications for bipolar disorder: understanding the mechanisms of action.

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1
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

Abstract

Modern psychiatry is beginning to understand mood disorders according to a neuroplastic rather than a neurochemical model. Neuroplasticity is the brain's ongoing ability to restructure itself over a lifetime by making new neural connections. Patients with mood disorders have been found to have neuroplastic changes, including reductions in hippocampal volume, glial and neuronal cell density, and brain-derived neurotrophic factor. Using the neuroplasticity model of mood disorders, specific neurobiological mechanisms can be targeted for treatment.

PMID:
19222977
[Indexed for MEDLINE]
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