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Clin Infect Dis. 2009 Mar 15;48(6):822-6. doi: 10.1086/596768.

Do benefits of earlier antiretroviral treatment initiation outweigh harms for individuals at risk for poor adherence?

Author information

1
Department of Medicine, Section of General Internal Medicine, Yale University, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA. ronald.braithwaite@va.gov

Abstract

Clinicians may defer antiretroviral treatment for patients with suboptimal adherence. We used a validated computer simulation of HIV disease progression to compare alternative treatment thresholds for patients with suboptimal adherence. Earlier treatment increased life expectancy across a wide adherence range (50%-100% of doses taken). Delaying treatment for patients with suboptimal adherence may not always be appropriate.

PMID:
19210173
PMCID:
PMC3032571
DOI:
10.1086/596768
[Indexed for MEDLINE]
Free PMC Article

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