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Mol Cell. 2009 Jan 30;33(2):137-8. doi: 10.1016/j.molcel.2009.01.005.

BRCTing up is hard to do.

Author information

1
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA. df.stern@yale.edu

Abstract

In this issue of Molecular Cell, Usui et al. (2009) show that Mec1-phosphorylated Rad9 SCD interacts with the BRCT domain, promoting oligomerization. This sustains the DNA damage checkpoint and is suppressed by Rad53 phosphorylation in a negative feedback circuit.

PMID:
19187753
DOI:
10.1016/j.molcel.2009.01.005
[Indexed for MEDLINE]
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