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J Cell Biochem. 2009 May 1;107(1):6-10. doi: 10.1002/jcb.22060.

From sextant to GPS: twenty-five years of mapping the genome with ChIP.

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1
School of Medicine, Yale University, New Haven, Connecticut 06510, USA.

Abstract

Since its inception, ChIP technology has evolved immensely. Technological advances have improved its specificity and sensitivity, its scale has expanded to a genome-wide level, and its relative ease of use has made it a virtually ubiquitous tool. This year marks the 25th anniversary of the development of ChIP. In honor of this milestone, we briefly revisit its history, offer a review of recent articles employing ChIP on a genome-wide scale, and lay out our views for the future of ChIP.

PMID:
19180576
DOI:
10.1002/jcb.22060
[Indexed for MEDLINE]

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