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Bioconjug Chem. 2009 Feb;20(2):193-6. doi: 10.1021/bc800432n.

Cationic nucleoside lipids based on a 3-nitropyrrole universal base for siRNA delivery.

Author information

1
Centre Interdisciplinaire de Nanosciences de Marseille CINaM, UPR-CNRS 3118, Université Aix-Marseille II, Luminy, Case 913, 13288 Marseille Cedex 09, France.

Abstract

Cationic nucleoside lipids based on a 3-nitropyrrole universal base were prepared from D-ribose using a straightforward chemical synthesis. Several studies including DLS, TEM, and ethidium bromide (EthBr) assay demonstrated that these amphiphilic molecules form supramolecular organizations of nanometer size in aqueous solutions and are able to bind nucleic acids. siRNA knockdown experiments were performed with these nucleolipids, and we observed protein knockdown activity similar to the siPORT NeoFX positive control. No significant cytotoxicity was found.

PMID:
19159294
PMCID:
PMC2819530
DOI:
10.1021/bc800432n
[Indexed for MEDLINE]
Free PMC Article

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