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Diabetes Care. 2009 Mar;32(3):387-93. doi: 10.2337/dc08-0800. Epub 2008 Dec 23.

Comparison of glycemic variability associated with insulin glargine and intermediate-acting insulin when used as the basal component of multiple daily injections for adolescents with type 1 diabetes.

Author information

1
Department of Pediatrics and Medicine, Pediatric Patient-Oriented Research Unit, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, Missouri, USA. white_n@kids.wustl.edu

Abstract

OBJECTIVE:

To compare the glucose variability associated with insulin glargine and NPH/Lente insulin used as the basal insulin component of a multiple daily injection (MDI) regimen in pediatric patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS:

Continuous glucose monitoring data were collected from a subset of patients (n = 90) who agreed to use a continuous glucose monitoring system during an active-controlled, randomized, open-label study evaluating the safety and efficacy of insulin glargine and NPH/Lente insulin used with insulin lispro as part of an MDI regimen.

RESULTS:

Treatment with insulin glargine resulted in significant reductions in glucose variability as measured by the SD of glucose values (adjusted mean change from baseline to week 24: -13.4 mg/dl [-0.74 mmol/l]; P <or= 0.05), mean amplitude of glycemic excursion (-34.4 mg/dl [-1.91 mmol/l]; P <or= 0.0001), and M value (-9.6 mg/dl [-0.53 mmol/l]; P <or= 0.03). The corresponding reductions in glucose variability for NPH/Lente were not significant.

CONCLUSIONS:

Insulin glargine is associated with greater reductions in glucose variability than NPH/Lente insulin in pediatric patients with type 1 diabetes.

PMID:
19106380
PMCID:
PMC2646014
DOI:
10.2337/dc08-0800
[Indexed for MEDLINE]
Free PMC Article
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